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Faculty

Bhagavatula Moorthy, Ph.D.

Bhagavatula Moorthy, Ph.D.

Academic Appointments

  • Associate Professor of Pediatrics—Neonatology

Current Positions in Professional Organizations

  • Member, Xenobiotic, Nutrition, Disposition, and Action Study Section, NIH (2005-2009).
  • Secretary, Gulf coast Chapter of the Society of Toxicology (2008-2009).

Professional History

  • Ph.D., Indian Institute of Science, Bangalore, India, 1988
  • Postdoctoral Fellow, Department of Biochemistry, Medical College of Wisconsin, Milwaukee WI, 1988–1990
  • Research Associate, Department of Pharmacology, Baylor College of Medicine, Houston TX, 1990–1991

Academic Interests

  • Molecular mechanisms of lung injury induced by hyperoxia
  • Molecular regulation of hepatic and pulmonary cytochrome P4501A expression by oxygen, and the role of CYP1A enzymes in oxygen toxicity
  • Regulation of CYP1A enzymes by polycyclic aromatic hydrocarbons, in relation to chemical carcinogenesis.
  • Mechanisms of formation and repair of exogenous and endogenous DNA adducts, and their role in carcinogenesis and oxygen toxicity.

Recent Publications

  1. Kondraganti, S.R., Jiang, W., Jaiswal, A.K. and Moorthy, B. Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol. Sci., 2008, 102: 337-344.
  2. Moorthy, B., Muthiah, K., Fazili, I.S., Kondraganti, S.R., Wang, L., Couroucli, X.I., and Jiang, W. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem. Biophys. Res. Commun., 2007; 354: 1071-1077.
  3. Das A, Kole L, Wang L, Barrios R, Moorthy B, Jaiswal AK. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Free Radic Biol Med 2006, 40:1843–1856.
  4. Couroucli XI, Wei Y-H, Jiang W, Evey LW, Barrios R, Moorthy B. Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: Implications for lung injury. Pediatr Res 2006; 59:401–406. 
  5. Sinha A, Muthiah K, Jiang W, Couroucli XI, Barrios R, and Moorthy B. Attenuation of hyperoxic lung injury by the cytochrome P4501A1 inducer, b-naphthoflavone. Toxicol Sci, 2005; 87:204-12.